Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Oral Mucosal Melanosis IntechOpen Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Oral Melanotic Macule: Symptoms and Treatment Skinsight Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier Hunziker syndrome