Tylenol depletes something called glutathione. Glutathione is a master antioxidant and your first line of protection against environmental toxins. It detoxifies and protects your cells. It protects your immune system and Acetaminophen overdose in children CMAJ Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation