A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health NSAIDs & Acetaminophen: ditki medical and biological sciences Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol's Impact on Glutathione and Liver Damage What To Avoid When Taking Glutathione